高原低氧环境对兔牙周炎模型血清和牙龈组织中超氧化物歧化酶活力的影响

[摘要] 目的 观察高原低氧和平原常氧环境下兔牙周炎动物模型中超氧化物歧化酶（SOD）的活力情况，以探讨高原牙周病的发病机制。方法 选取40只雄性白兔随机分为4组，即常氧对照组、常氧实验组（牙周炎动物模型）、

低氧对照组、低氧实验组（牙周炎动物模型）。采用正畸结扎丝结扎下颌中切牙与牙周炎食谱的方法建立牙周炎动

物模型。动态观察动物体重变化，实验8周后，检测各组动物牙周各项临床指标和血清、牙龈组织中的总SOD活力。结果 8周时，与低氧对照组和常氧实验组相比，低氧实验组的总SOD活力下降（P＜0.05），体重和牙周临床指标存在统计学差异（P＜0.01）。血清及牙龈组织中总SOD活力与附着丧失（AL）呈负相关（r值分别为-0.980和-0.804，P

[关键词] 高原； 低氧； 牙周炎； 超氧化物歧化酶

[中图分类号] R 781.4 [文献标志码] A [doi] 10.3969/j.issn.1000-1182.2012.03.006

Effects of the activity of superoxide dismutase in blood serum and gingival tissues of rabbit in periodontitis model after hypoxia exposure at high altitude Wu Xi1, Huang Jingjing1, Zhang Gang1, Tan Yinghui1, Gao Yuqi2. （1. Dept. of Stomatology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China; 2. High Altitude Military Medical Faculty, The Third Military Medical University, Chongqing 400037, China）

[Abstract] Objective To observe the activity of superoxide dismutase（SOD） in rabbit periodontitis model in nor-

moxia and hypoxia environment, and to research the pathogenesis of periodontal diseases at high altitude. Methods Fourty male rabbits were randomly divided into four groups: Normoxia control group, normoxia periodontitis group（pe-

riodontitis models）, hypoxia control group, hypoxia periodontitis group（periodontitis models）. The periodontitis models

were established by ligating the two central incisors of mandible and raised by periodontitis diets. The weights of four groups were dynamically observed. After eight weeks, the clinical periodontal indexes and the activity of total-SOD（T-

SOD） in blood serum and gingival tissues in all groups were detected. Results The activity of T-SOD of hypoxia periodontitis group was significantly lower than normoxia periodontitis group and hypoxia control group（P＜0.05）, the

weights and clinical periodontal indexes were also dramatically different（P＜0.01）. The activity of SOD in serum was

positively correlated with the gingival tissues（r=0.846, P

-0.804, P