1和普米克令舒雾化吸入治疗毛细支气管炎临床观察'> 维生素K1和普米克令舒雾化吸入治疗毛细支气管炎临床观察

时间:2022-10-25 02:42:32

1和普米克令舒雾化吸入治疗毛细支气管炎临床观察'> 维生素K1和普米克令舒雾化吸入治疗毛细支气管炎临床观察

[摘要] 目的 探讨维生素K1和普米克令舒雾化吸入治疗毛细支气管炎的疗效。 方法 将2008年10月~2011年3月我院收治的100例毛细支气管炎患儿随机分为两组,治疗组54例,应用维生素K1和普米克令舒氧驱动雾化吸入治疗;对照组46例,应用硫酸庆大霉素注射液+糜蛋白酶+地塞米松雾化。两组均予常规抗炎、吸痰、吸氧等治疗。 结果 治疗组喘憋症状、喘鸣音消失时间、总住院时间均少于对照组(P < 0.01), 两组疗效比较有显著差异(P < 0.05)。 结论 维生素K1和普米克令舒氧驱动雾化吸入治疗毛细支气管炎疗效显著,值得临床推广。

[关键词] 维生素K1;普米克令舒;雾化吸入;毛细支气管炎

[中图分类号] R726.82 [文献标识码] B [文章编号] 1673—9701(2012)27—0150—02

Clinical observation of aerosol inhalation with vitamin K1 and Pulmicort Respule in the treatment of capillary bronchitis

FAN Jibin XIANG Xiaoming

Department of Pediatrics, People's Hospital of Jingshan County in Hubei Province,Jingshan 431800,China

[Abstract] Objective To discuss the efficiency of aerosol inhalation with Vitamin K1 and Pulmicort respule in treating capillary bronchitis. Methods From Oct 2008 to Mar 2011,100 cases capillary bronchitis in our hospital were randomly divided into two groups,the treatment group contained 54 cases,the control group had 46 cases,the treatment group was treated by aerosol inhalation with Vitamin K1 and Pulmicort respule. The control group by aerosol inhalation with gentamycin sulfate injection,chymotrypsin and dexamethasone. All cases were treated with anti—infective,inspiriting oxygen and eliminating sputum. Results The treatment group succeeded in eliminating symptoms like asthma,dyspnea and wheezing sound,and considerably reducing days in hospital. The group had significant difference compared with the control group(P < 0.01).The effective rate of the treatment was better than that of the control group(P < 0.05). Conclusion Aerosol inhalation with Vitamin K1 and Pulmicort respule in the treatment of capillary bronchitis could significantly improve symptoms,shorten course and is worthy for being widely used.

[Key words] Vitamin K1; Pulmicort Respules; Capillary bronchitis; Aerosol inhalation

毛细支气管炎婴幼儿常见,是一种以严重喘憋为主要表现的特殊类型的肺炎,严重时合并呼吸衰竭及心力衰竭,目前尚无特效治疗手段,临床常用糖皮质激素及氨茶碱静脉用药治疗,不仅疗效欠佳,且全身反应重。我科采用维生素K1和普米克令舒联合氧驱动雾化吸入治疗毛细支气管炎,疗效显著,现报道如下。

1 资料与方法

1.1 一般资料

选择2008年10月~2011年3月收治的入院患儿100例,符合毛细支气管炎的诊断标准[1],排除气管异物、先天性心脏病、支气管肺发育不良等疾病。随机分为两组,对照组54例与治疗组46例。其中对照组男30例,女24例;治疗组男24例,女22例,各组年龄3~11个月。入院时均有阵发性咳嗽、喘憋、呼吸增快,肺部可闻及喘鸣音。两组的年龄、性别、病程、喘憋程度均无差异(P > 0.05)。

1.2 治疗方法

包括给氧、吸痰、抗感染、保持呼吸道通畅、维持水电解质平衡等。此外,治疗组用普米克令舒1 mL+维生素K1 5 mg 加生理盐水至10 mL;对照组用普通雾化,雾化液为硫酸庆大霉素注射液2万U+糜蛋白酶4 000 mg+地塞米松2 mg加生理盐水至10 mL,均采用德国百瑞简易雾化器(PARILCD),氧驱动雾化吸入,氧流量(4~6) L/min,2次/d,每次10~20 min。

1.3 疗效标准

显效:治疗3 d内喘憋明显缓解,肺部哮鸣音及湿啰音减少或消失;有效:治疗7 d内,喘憋明显减轻,肺部哮鸣音及湿啰音减少或消失;无效:治疗7 d以上咳嗽喘憋症状无改善,肺部可闻及哮鸣音或湿啰音。

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