丹红注射液治疗老年人椎基底动脉供血不足临床疗效观察

[摘要] 目的 观察丹红注射液治疗老年人椎－基底动脉供血不足（VBI）患者的临床疗效。 方法 将64例椎基底动脉供血不足患者随机分为两组，治疗组（32例）用生理盐水250 mL加入丹红注射液20 mL，静脉滴注，1次/d；对照组（32例）用生理盐水250 mL加入丹参注射液20 mL，静脉滴注，1次/d，两组均治疗14 d为1个疗程。治疗后观察临床疗效、经颅彩色多普勒超声（TCD）血流速及血液流变学变化。 结果 治疗组有效率为90.63％，对照组为71.88％，两组疗效比较差异有高度统计学意义（P < 0.01）；TCD血流速检测两组治疗后与治疗前比较有显著性增加（P < 0.01），治疗组与对照组比较亦有明显增加（P < 0.05）；血液流变学各项指标治疗组治疗后与治疗前比较差异有统计学意义（P < 0.01），对照组治疗后与治疗前比较无显著性差异（P > 0.05），治疗组与对照组治疗后比较差异有统计学意义（P < 0.05）。 结论 丹红注射液临床疗效显著，能明显增加椎－基底动脉血流量，改善微循环，降低血黏度。

[关键词] 丹红注射液；椎基底动脉；彩色多普勒超声；血液流变学；临床疗效

[中图分类号] R441.2 [文献标识码] A [文章编号] 1673-7210（2012）07（a）-0109-03

Clinical observation on the therapeutic effect of Danhong Injection in the treatment of senior patients with vertebrobasiIar insufficiency

DENG Yuhang YANG Yichao ZHANG Liwen

Department of Emergency, Shenzhen Futian Traditional Chinese Medical Hospital Affiliated to Hu'nan University of Chinese Medicaly, Guangdong Province, Shenzhen 518034, China

[Abstract] Objective To observe the clinical therapeutic effect of Danhong Injection in the treatment of senior patients with vertebrobasilar insufficiency (VBI). Methods 64 patients were randomly divided into treatment group (n = 32) and control group (n = 32). The treatment group was treated by normal saline (250 mL) plus Danhong Injection (20 mL) with Mainline one time each day. The control group was treated by normal saline (250 mL) plus Danshen Injection (20 mL) with Mainline one time each day. The Period of treatment is lasting 14 days. After 14 days' therapy, the clinical therapeutic effect and changes in the parameters of TCD and hemorheology were observed. Results The total effective rate in the treatment group was 90.63% but 71.88% in control group (P < 0.01). Through TCD, measuring blood flow velocity, it was significantly increased after treatment than before treatment in two groups (P < 0.01), the treatment group was significant increased than that of control group (P < 0.05). After therapy, the parameters of hemorheology after therapy compared with before therapy in treatment group, there was significant difference (P < 0.01), and there was no significant difference in control group (P < 0.05). Conclusion Danhong Injection shows a significant clinical therapeutic effect in the treatment of patients with VBI. It is able to increase blood flow vaule with VBI. It is able to improve the Microcirculation and to decrease the Blood viscosity.

[Key words] Danhong Injection; VBI; Color doppler ultrasonography; Hemrrheology；Clinical therapeutic effect