复方甘草酸苷联合高频电刀对女性尖锐湿疣患者Th1/Th2 细胞因子的影响及疗效观察

[摘要] 目的 探讨复方甘草酸苷联合高频电刀对女性尖锐湿疣患者Th1/Th2 细胞因子的影响及疗效。 方法 女性尖锐湿疣患者70例，随机分为两组：复方甘草酸苷联合高频电刀治疗1组；单纯高频电刀治疗2组。治疗前及治疗后1个月分别用ELISA 法检测各组患者外周血细胞因子IL—2、IL—4、IL—10及IFN—γ的表达水平。另设健康女性对照组25例，检测项目同上。 结果 ①复方甘草酸苷联合高频电刀治疗1组疗效明显高于单纯高频电刀治疗2组（χ2 =5.29， P < 0.05）；②女性尖锐湿疣患者与健康女性外周血Th1/Th2 细胞因子的表达比较：女性尖锐湿疣患者外周血中Th1型细胞因子IL—2（t = 4.012， P < 0.05）和IFN—γ（t=3.880， P < 0.05）的表达水平显著降低；而Th2型细胞因子IL—4（t = 2.694， P < 0.05）和IL—10（t = 3.069， P < .05）的表达水平显著升高；③治疗1个月后复方甘草酸苷联合高频电刀治疗1组相比单纯高频电刀治疗2组对Th1/Th2 平衡具有更明显的调节作用。 结论 复方甘草酸苷联合高频电刀治疗女性尖锐湿疣可提高疗效，通过调节患者Th1/Th2 细胞因子的平衡状态，改善患者的细胞免疫功能。

[关键词] 复方甘草酸苷；高频电刀；尖锐湿疣；Th1/Th2 细胞因子

[中图分类号] R711.7 [文献标识码] B [文章编号] 1673—9701（2012）25—0070—03

The influence of compound glycyrrhizin plus high frequency radio—surgery procedures on Th1/Th2 related cytokines and curative effect of female condyloma acuminatum patients

XU Xuejuan1 MA Xueliang2 GUO Hongfei2

1.Department of Obstetrics and Gynecology， Tengzhou Central People′s Hospital Affiliated to Jining School of Medicine， Tengzhou 277500， China； 2.Department of Dermatology，Tengzhou Central People′s Hospital Affiliated to Jining School of Medicine， Tengzhou 277500， China

[Abstract] Objective To observe the influence of compound glycyrrhizin on Th1/Th2 related cytokines of female patients with condyloma acuminatum （CA） after high frequency radio—surgery procedures treatment. Methods Totally 70 cases of female CA were randomly divided into two groups. The first group was treated with compound glycyrrhizin after removed by high frequency radio—surgery procedures. The second group was only removed by high frequency radio—surgery procedures. In the groups above，the levels of IL—2， IL—4， IL—10 and IFN—γ in serum of female CA and control group were determined by ELISA before therapy and one month after therapy. Another control group was made up of twenty—five healthy cases accepting the same assays as the above. Results （1）The efficacy in the first treatment group was better than the second group（χ2=5.29， P < 0.05）；（2）Compared with the control group，the levels of IL—2 （t = 4.012， P < 0.05） and IFN—γ （t = 3.880， P < 0.05） in patients with female CA were lower before treatment； While the levels of IL—4（t = 2.694，P < 0.05） and IL—10 （t = 3.069， P < 0.05） were higher before treatment； （3）Compared with the second treatment group，the first treatment group has more significant regulatory role for Th1/Th2 related cytokines. Conclusion The compound glycyrrhizin plus high frequency radio—surgery procedures can improve efficacy and the immune function state by regulate the balance of Th1/Th2 related cytokines in the female CA.