比较mFOLFOX―6方案与FOLFILI方案治疗转移性结直肠癌的临床疗效及不良反应

【摘要】 目的 ψ移性结直肠癌患者接受mFOLFOX-6方案与FOLFILI方案治疗的疗效以及不良反应进行观察分析。方法 50例转移性结直肠癌患者作为本次研究对象， 根据患者治疗方案的不同分为实验组及对照组， 各25例。实验组接受mFOLFOX-6方案治疗， 对照组接受FOLFILI方案治疗。对比两组患者的疗效以及不良反应发生情况。结果 治疗后， 实验组患者的总有效率为40.00%、控制率为84.00%， 对照组患者的总有效率为40.00%、控制率为80.00%， 两组对比差异均无统计学意义（P>0.05）。实验组外周神经毒性发生率84.00%高于对照组的32.00%， 延迟性腹泻发生率16.00%、胆碱能综合征发生率0均低于对照组的44.00%、24.00%， 差异均具有统计学意义 （P0.05）。结论 转移性结直肠癌患者接受mFOLFOX-6方案与FOLFILI方案进行治疗， 均可取得较好的效果， 两种治疗方案均可导致患者出现不良反应情况， 其中mFOLFOX-6方案治疗的主要不良反应为外周神经毒性， FOLFILI方案治疗的主要不良反应为胆碱能神经综合征与延迟性腹泻， 临床可根据转移性直肠癌患者的具体病情以及耐受情况， 为其选择合理的方案进行治疗。

【关键词】 转移性结直肠癌；FOLFILI方案；mFOLFOX-6方案

DOI：10.14163/ki.11-5547/r.2017.18.056

【Abstract】 Objective To observe and analyze the curative effect and adverse reactions of metastatic colorectal cancer patients treated with mFOLFOX-6 and FOLFILI regimen. Methods A total of 50 metastatic colorectal cancer patients as study subjects were divided by different regimens into experimental group and control group， with 25 cases in each group. The experimental group received mFOLFOX-6 regimen for treatment， and the control group received FOLFILI regimen for treatment. Comparison were made on curative effect and occurrence of adverse reactions in two groups. Results After treatment， the experimental group had total effective rate as 40.00% and control rate as 84.00%， while the control group had total effective rate as 40.00% and control rate as 80.00%， and the difference had no statistical significance （P>0.05）. The experimental group had higher incidence of peripheral neurotoxicity as 84.00% than 32.00% in the control group， and lower incidence of delayed diarrhea as 16.00% and incidence of cholinergic syndrome as 0 than 44.00% and 24.00% in the control group. Their difference had statistical significance （P0.05）. Conclusion Both mFOLFOX-6 and FOLFILI regimen shows good effect for patients with metastatic colorectal cancer， and both regimens lead to adverse reactions， with main adverse reaction of mFOLFOX-6 regimen as peripheral neurotoxicity， and main adverse reaction of FOLFILI regimen as cholinergic nerve syndrome and delayed diarrhea. Reasonable regimens should be selected according to the specific condition of metastatic colorectal cancer patients.

【Key words】 Metastatic colorectal cancer； FOLFILI regimen； mFOLFOX-6 regimen